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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Related Experiment Video

Updated: Mar 2, 2026

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
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Karyomegalic interstitial nephritis.

N Bennani Guebessi1, M Karkouri2

  • 1Department of pathology, UHC of IBN RUSCHD, Casablanca, Morocco. nis.bennani@gmail.com.

CEN Case Reports
|May 17, 2017
PubMed
Summary
This summary is machine-generated.

Karyomegalic interstitial nephritis is a rare kidney disease. This case study highlights a young man with respiratory issues and kidney failure, revealing significant cell enlargement in his kidneys.

Keywords:
Interstitial nephritisKaryomegalyRenal failure

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Area of Science:

  • Nephrology
  • Pathology
  • Genetics

Background:

  • Karyomegalic interstitial nephritis (KIN) is a rare, progressive kidney disease.
  • The underlying causes and mechanisms of KIN remain largely unknown.
  • This condition is characterized by enlarged cell nuclei within the kidney tubules.

Purpose of the Study:

  • To report a unique case of KIN in a young adult.
  • To describe the clinical presentation and pathological findings.
  • To contribute to understanding the pathogenesis of KIN.

Main Methods:

  • Case report of a 22-year-old male patient.
  • Review of medical history including recurrent respiratory infections and bronchiectasis.
  • Analysis of renal biopsy findings.

Main Results:

  • The patient presented with progressive renal failure.
  • Renal biopsy confirmed chronic tubulointerstitial nephritis.
  • A striking feature was marked karyomegaly of the tubular epithelium.

Conclusions:

  • This case underscores the presentation of KIN in young adults.
  • The observed karyomegaly in tubular cells is a key pathological hallmark.
  • Further research is needed to elucidate the pathogenesis of KIN.