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Published on: December 22, 2016
Renal biopsy cases in myeloproliferative neoplasms (MPN)
1Tenri Institute of Medical Research, 200 Mishima-cho, Tenri, Nara, Japan. fujiko@tenriyorozu.jp.
Abstract:
We performed renal biopsy in three cases complicated by myeloproliferative neoplasms (MPN). Although several cases of glomerulonephritis associated with MPN have been reported, the etiologies of the renal disorders were not established (Plomley et al., Aust NZ J Med, 13:125-129, 1983; Sharma et al., Nephron, 69:361, 1995; Kanauchi et al., Intern Med, 33:36-40, 1994; Kasuno et al., Nephrol Dial Transplant, 12:212-215, 1997; Au et al., Am J Kid Dis, 34:889-893, 1999; Kosch et al., Nephrol Dial Transplant, 15:1710-1711, 2000; Oymak et al., Nephron, 86:346-347, 2000; Chun et al., Am J Nephrol, 20:344-346, 2000; Chung et al., Am J Nephrol, 22:397-401, 2002; Asaba et al., Clin Exp Nephrol, 7:296-300, 2003; Haraguchi et al., Clin Exp Nephrol, 10:74-77, 2006; Saigusa et al., J Nephrol, 19:656-658, 2006; Okuyama et al., Clin Nephrol, 6:412-415, 2007; Nishi et al., Clin Nephrol, 5:393-398, 2010; Ulusoy et al., Intern Med, 49:2477, 2010). A review of previous reports of renal biopsy cases with MPN in the English literature suggested that circulation control is important for the treatment of renal disorders that mimic glomerulonephritis in MPN.
Insights
Renal biopsies in myeloproliferative neoplasms (MPN) cases reveal kidney disorders. Managing circulation is key for treating MPN-related glomerulonephritis mimics.
Area of Science:
- Nephrology
- Hematology
- Oncology
Background:
- Myeloproliferative neoplasms (MPN) can present with various renal complications.
- Glomerulonephritis is a recognized renal disorder associated with MPN, but its exact etiology remains unclear.
- Previous case reports highlight the need for further investigation into MPN-associated kidney diseases.
Purpose of the Study:
- To investigate renal pathology in patients with myeloproliferative neoplasms.
- To review existing literature on renal biopsy findings in MPN cases.
- To identify potential therapeutic strategies for MPN-related renal disorders.
Main Methods:
- Performed renal biopsy in three patients diagnosed with myeloproliferative neoplasms.
- Conducted a comprehensive review of English literature focusing on renal biopsy cases associated with MPN.
- Analyzed the etiologies and clinical presentations of renal disorders in the context of MPN.
Main Results:
- Renal biopsy revealed specific pathologies in the three MPN cases.
- Literature review indicated a pattern of renal disorders mimicking glomerulonephritis in MPN patients.
- The underlying causes of these renal manifestations were not consistently established in prior reports.
Conclusions:
- Renal disorders, including glomerulonephritis mimics, are significant complications of myeloproliferative neoplasms.
- Effective management of circulation appears crucial for treating these MPN-associated renal conditions.
- Further research is warranted to elucidate the precise mechanisms and optimize treatment strategies.
