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Updated: Mar 2, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Published on: September 20, 2018
[Adhesion molecule JAM-A, its function and mechanism of epigenetic regulation]
B I Kuznik1, V Kh Khavinson2,3,4, S I Tarnovskaya2,5
1Chita State Medical Academy, Chita, 672000, Russian Federation.
Abstract:
The article represents evidence about structures, properties and functions of adhesion molecule JAM-A/1 belonging to JAM subfamily. This protein plays an important role in epithelial tight junction formation and immune function. Current article focuses on the role of JAM-A protein in pathogenesis associated to ageing: atherosclerosis, apoplexy, thrombosis, hypertension, ophthalmological pathology. We propose short peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly could influence on F11R gene expression that leads to recovery of JAM-A synthesis in cells.
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