Related Experiment Video
Updated: Mar 2, 2026
Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
Published on: August 11, 2023
[Clinical and pathogenetic features of ischemic stroke among representatives of different gender and age]
V S Myakotnykh1, E Y Kravtsova2, G A Martynova2
1Ural State Medical University, Ekaterinburg, 620036, Russian Federation; vmaykotnykh@yandex.ru.
Insights
Ischemic stroke risk factors vary by age and gender. Atherothrombotic strokes are more common in older adults, while younger individuals experience hemodynamic and lacunar types. Risk factor prevalence shifts with age and sex.
Area of Science:
- Neurology
- Epidemiology
- Public Health
Background:
- Ischemic stroke is a leading cause of disability and death worldwide.
- Understanding the influence of age, sex, and pathogenic subtypes on risk factors is crucial for targeted prevention strategies.
- Previous research has identified various risk factors, but their interplay with demographic and etiological aspects requires further elucidation.
Purpose of the Study:
- To analyze the dependence of ischemic stroke pathogenic types, background pathologies, and risk factors on patient sex and age.
- To identify age- and sex-specific risk factor profiles for different ischemic stroke subtypes.
Main Methods:
- Observational study involving 1410 patients with ischemic stroke.
- Classification of ischemic stroke into four main pathogenic types: atherothrombotic, cardioembolic, hemodynamic, and lacunar.
- Statistical analysis to assess the relationship between stroke type, background factors, risk factors, and demographic variables (age, sex).
Main Results:
- Atherothrombotic ischemic stroke is more prevalent in older adults, while working-age individuals more frequently experience hemodynamic and lacunar strokes.
- In working-age men, atherothrombotic strokes were observed more frequently.
- The significance of hypertension decreases with age, whereas cerebral atherosclerosis, ischemic heart disease, and cardiac arrhythmias become more important.
- Key risk factors for older adults include physical inactivity, overweight, and dyslipidemia, while smoking and stress are more relevant for working individuals.
- Gender-specific differences in risk factor prevalence exist but vary across age groups and stroke subtypes, being less distinct in older adults.
Conclusions:
- Ischemic stroke etiology and risk factor profiles exhibit significant variations based on age and sex.
- Prevention and management strategies for ischemic stroke should be tailored to specific age groups and pathogenic subtypes, considering the evolving role of risk factors across the lifespan.
- These findings highlight the need for personalized approaches in addressing the complex interplay of factors contributing to ischemic stroke.
Abstract:
We observed 1410 patients of different gender and age with ischemic stroke of 4 main clinical and pathogenic types - atherothrombotic, cardioembolic, hemodynamic and lacunar. The dependence of the pathogenic type of stroke, background options for stroke pathology and risk factors of stroke on sex and age of patients was analyzed. We founded out that atherothrombotic ischemic stroke is more common for persons of retirement age, and in working paeople - gap and hemodynamic once, although atherothrombotic strokes in this age group were more frequently observed among men. The importance of hypertension in the development of ischemic stroke reduces with age, but the role of cerebral atherosclerosis, ischemic heart disease and cardiac arrhythmias increases. As risk factors for ischemic stroke in the pension age physical inactivity, overweight and dyslipidemia play the main role, when reducing the role of smoking and stress, more relevant for working people. The frequency of the presence of certain risk factors and background for ischemic stroke disease depends on the patient's gender, but in different age periods and under different pathogenic types of ischemic stroke this dependence changes and in people of retired age it is less distinct than in working people.
More Related Videos
Related Concept Videos
01:17Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
01:30Coronary Artery Disease I: Introduction
01:30Coronary Artery Disease III: Clinical Manifestations
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
01:27Regulation of Stroke Volume
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...