Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Fibril-associated Collagen

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

How do we use smart blood refrigerators at our hospitals in North America?

Transfusion·2026

Same author

Endoscopic vacuum therapy.

iGIE : innovation, investigation and insights·2026

Same author

Guidewires in GI endoscopy.

iGIE : innovation, investigation and insights·2026

Same author

Biliary and pancreatic stents.

iGIE : innovation, investigation and insights·2026

Same author

Comparative analysis of ABO titers in traditional cryoprecipitate versus INTERCEPT Fibrinogen Complex.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2025

Same author

Minimum standards for training in colorectal endoscopic mucosal resection among advanced endoscopy trainees.

Endoscopy international open·2025

Search research articles

Related Experiment Video

Updated: Mar 2, 2026

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

Link protein N-terminal peptide and fullerol promote matrix production and decrease degradation enzymes in rabbit

Ching-Hua Yeh^1,2, Dennis Chen¹, Bayan Aghdasi¹

¹a Department of Orthopaedic Surgery , University of Virginia , Charlottesville , VA , USA.

Connective Tissue Research

|May 17, 2017

Summary

This summary is machine-generated.

Link protein N-terminal peptide (LN) and fullerol combat disc degeneration by promoting matrix production and reducing inflammation. This combination therapy offers a promising approach for treating back pain caused by intervertebral disc degeneration.

Keywords:

Back pain fullerol inflammation intervertebral disc degeneration link N peptide

More Related Videos

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

Related Experiment Videos

Last Updated: Mar 2, 2026

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

Area of Science:

Biomedical Engineering
Regenerative Medicine
Cell Biology

Background:

Intervertebral disc degeneration is a primary cause of back pain.
Current treatments lack regenerative capabilities.
Therapies targeting inflammation and matrix degradation are needed.

Purpose of the Study:

To evaluate the combined regenerative potential of link protein N-terminal peptide (LN) and fullerol.
To assess their effects on annulus fibrosus (AF) cells in a 3D culture model.

Main Methods:

Utilized a 3D cell culture model of annulus fibrosus (AF) cells.
Induced degeneration using Interleukin-1α (IL-1α).
Assessed matrix production via real-time PCR and glycosaminoglycan assay; measured inflammatory mediators and matrix metalloproteinases (MMPs).

Main Results:

Fullerol and LN, individually and combined, counteracted IL-1α-induced AF cell degeneration.
The combination of fullerol and LN demonstrated the greatest effect on matrix production.
Both agents reduced pro-inflammatory mediators (IL-6, COX-2) and MMPs (MMP-1, -2, -9, -13).

Conclusions:

LN and fullerol promote matrix production in AF cells.
These agents exhibit anti-inflammatory and anti-catabolic effects.
The combination therapy shows significant potential for preventing or reversing disc degeneration.