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Associations between glycaemic deterioration and aortic stiffness and central blood pressure: the ADDITION-PRO Study

Nanna B Johansen1, Signe S Rasmussen, Niels Wiinberg

  • 1aResearch Centre for Prevention and Health, Centre for Health, Capital Region of Denmark, Glostrup bSteno Diabetes Center Copenhagen, Gentofte cDanish Diabetes Academy, Odense dDepartment of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød eDepartment of Clinical Physiology, Frederiksberg Hospital, Frederiksberg fDepartment of Medical Research, Holstebro Hospital and University of Aarhus, Holstebro gDepartment of Public Health, Section of General Practice, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark.

Journal of Hypertension
|May 17, 2017
PubMed

Insights

Diabetes risk impacts aortic stiffness. Higher HbA1c at screening correlated with increased aortic stiffness (aPWV) and lower central diastolic blood pressure (DBP). Glycemic changes over time did not independently affect these measures.

Area of Science:

  • Cardiovascular disease research
  • Metabolic disorders and diabetes
  • Public health screening programs

Background:

  • Diabetes risk assessment is crucial for early intervention.
  • Central hemodynamics, including aortic stiffness and central blood pressure, are key indicators of cardiovascular health.
  • Understanding the relationship between glycemic control and hemodynamic parameters is vital for managing diabetes complications.

Purpose of the Study:

  • To investigate central hemodynamic profiles across different diabetes risk strata.
  • To analyze the association of glycated hemoglobin A1c (HbA1c) levels and changes with central hemodynamics.
  • To evaluate the impact of diabetes risk screening on cardiovascular health markers.

Main Methods:

  • A Danish population-based screening program identified seven diabetes risk groups.
  • Follow-up included 2048 individuals assessed for aortic stiffness (aPWV) and central blood pressure (BP) after 7.8 years.
  • Statistical analyses adjusted for confounders to examine HbA1c and its changes' impact on hemodynamics.

Main Results:

  • Individuals with high diabetes risk scores and impaired glucose tolerance exhibited higher aortic stiffness (aPWV), central systolic BP (SBP), diastolic BP (DBP), and pulse pressure.
  • A 1% point increase in screening HbA1c was linked to a 0.23 m/s increase in aPWV and a 1.35 mmHg decrease in central DBP.
  • Glycemic deterioration over the follow-up period showed no independent association with central hemodynamics.

Conclusions:

  • Dysglycemia, particularly at screening, is associated with increased future aortic stiffness.
  • While initial HbA1c levels influence central hemodynamics, glycemic changes over time do not independently predict aortic stiffness or central BP.
  • These findings highlight the importance of baseline glycemic status in assessing cardiovascular risk.
Abstract

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