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Updated: Mar 2, 2026

Reconstitution of Actin-Based Motility with Commercially Available Proteins
Published on: October 28, 2022
Actin in striated muscle: recent insights into assembly and maintenance
Joseph Dwyer1, Thomas Iskratsch1,2, Elisabeth Ehler3
1The Randall Division of Cell and Molecular Biophysics and The Cardiovascular Division, King's College London, British Heart Foundation Centre of Research Excellence, New Hunt's House, Guy's Campus, London, SE1 1UL, UK.
Abstract:
Striated muscle cells are characterised by a para-crystalline arrangement of their contractile proteins actin and myosin in sarcomeres, the basic unit of the myofibrils. A multitude of proteins is required to build and maintain the structure of this regular arrangement as well as to ensure regulation of contraction and to respond to alterations in demand. This review focuses on the actin filaments (also called thin filaments) of the sarcomere and will discuss how they are assembled during myofibrillogenesis and in hypertrophy and how their integrity is maintained in the working myocardium.
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