SH3 domains: modules of protein-protein interactions
Natalya Kurochkina1, Udayan Guha2
1Department of Biophysics, The School of Theoretical Modeling, PO Box 15676, Chevy Chase, MD, 20825, USA. info@schtm.org.
Abstract:
Src homology 3 (SH3) domains are involved in the regulation of important cellular pathways, such as cell proliferation, migration and cytoskeletal modifications. Recognition of polyproline and a number of noncanonical sequences by SH3 domains has been extensively studied by crystallography, nuclear magnetic resonance and other methods. High-affinity peptides that bind SH3 domains are used in drug development as candidates for anticancer treatment. This review summarizes the latest achievements in deciphering structural determinants of SH3 function.
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