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Related Experiment Video

Updated: Mar 2, 2026

Intraportal Transplantation of Pancreatic Islets in Mouse Model
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Modeling the Iatrogenic Pancreatic Cancer Risk After Islet Autotransplantation in Mouse.

E Dugnani1, V Pasquale1, D Liberati1

  • 1Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|May 17, 2017
PubMed
Summary

Transplanting pancreatic cells from a mouse model of pancreatic cancer did not cause liver metastasis in diabetic recipients. This suggests that KPC-derived cells may not pose a tumor development risk when transplanted.

Keywords:
animal models: murineautotransplantationcancer/malignancy/neoplasiadiabetes: new onset/posttransplantislet isolationislet transplantationtranslational research/science

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Area of Science:

  • Oncology
  • Transplantation Biology
  • Diabetology

Background:

  • Islet autotransplantation after pancreatectomy carries a risk of iatrogenic pancreatic cancer metastasis.
  • The LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) mouse model develops pancreatic ductal adenocarcinoma with high penetrance.

Purpose of the Study:

  • To assess the risk of liver metastasis following portal vein transplantation of KPC-derived islets and/or exocrine clusters into syngeneic diabetic recipients.
  • To evaluate if KPC-derived cells retain their tumorigenic potential in a non-cancerous recipient environment.

Main Methods:

  • KPC mouse islets and/or exocrine clusters were transplanted via the portal vein into wild-type diabetic recipients.
  • Treatment groups included KPC exocrine clusters, mixed KPC exocrine clusters and WT islets, KPC islets, and WT islets.
  • Hepatic metastasis was monitored using MRI and histology over 13 months.

Main Results:

  • No liver metastases were observed in any treatment group during the 13-month follow-up.
  • Overall survival did not differ significantly between the groups.
  • Two spontaneous tumors occurred: a liver hepatocellular tumor in the KPC exocrine cluster group and a malignant lymphoma in the WT islet group.

Conclusions:

  • Islets and/or exocrine clusters from the KPC mouse model do not appear to cause liver metastasis when transplanted via the portal vein into syngeneic diabetic recipients.
  • The study suggests that KPC-derived cells may not retain the same tumor development risk in this transplantation model.