Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Distribution of Cytoplasmic Content02:33

Distribution of Cytoplasmic Content

4.8K
Cytokinesis segregates a cell’s chromosomes and organelles into its daughter cells. Organelles divide and grow prior to cell division but cannot be synthesized de novo; therefore, cells must receive at least one copy of each organelle to survive. Currently, many of the details of how the organelles are distributed are not yet fully elucidated.
Distribution of cytoplasmic determinants
The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of...
4.8K
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

282.8K
In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
282.8K
Mitosis and Cytokinesis01:35

Mitosis and Cytokinesis

11.7K
In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
11.7K
Interphase00:54

Interphase

213.7K
The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.
213.7K
Interphase00:56

Interphase

11.5K
The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.
Phases of Interphase
Following each period of mitosis and cytokinesis, eukaryotic cells enter interphase, during which they grow and replicate...
11.5K
The Cell Cycle Control System02:11

The Cell Cycle Control System

14.7K
The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
14.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Annotating Interchromosomal Interactions at Sub-Megabase Resolution Using Network Clustering Coefficients.

bioRxiv : the preprint server for biology·2026
Same author

Distinct principles of genome compartmentalization in <i>Drosophila</i> and humans revealed by osmotic stress.

bioRxiv : the preprint server for biology·2026
Same author

Reversibility of Nuclear and 3D Genomic Changes in Non-Cancerous Fibroblasts After Constricted Migration.

bioRxiv : the preprint server for biology·2026
Same author

Spatial genome reorganization is associated with chromosomal breakage regions and karyotype changes induced by programmed DNA elimination.

bioRxiv : the preprint server for biology·2025
Same author

Rearrangement of 3D genome organization in breast cancer epithelial to mesenchymal transition and metastasis organotropism.

eLife·2025
Same author

Transient chromatin decompaction by histone deacetylation inhibition preferentially radiosensitizes cancerous breast epithelial cells at lower radiation doses.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Mar 2, 2026

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

629

Genome organization during the cell cycle: unity in division.

Rosela Golloshi1, Jacob T Sanders, Rachel Patton McCord

  • 1Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN, USA.

Wiley Interdisciplinary Reviews. Systems Biology and Medicine
|May 17, 2017
PubMed
Summary

Cell division dramatically reorganizes genome structure, requiring complex coordination for faithful segregation. Understanding these chromosome dynamics is crucial for preventing diseases linked to errors in cell division.

More Related Videos

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
08:33

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Published on: December 5, 2017

15.0K
Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
12:04

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

Published on: June 24, 2019

10.8K

Related Experiment Videos

Last Updated: Mar 2, 2026

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

629
Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
08:33

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Published on: December 5, 2017

15.0K
Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
12:04

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

Published on: June 24, 2019

10.8K

Area of Science:

  • Cell Biology
  • Genomics
  • Systems Biology

Background:

  • The cell cycle involves significant genome structural changes, transitioning between decondensed interphase and condensed mitotic chromosomes.
  • Faithful cell division requires accurate DNA replication and segregation of sister chromatids, balancing information storage with physical chromosome properties.

Purpose of the Study:

  • To elucidate the mechanisms behind observed chromosome structure changes during cell division.
  • To highlight the complex interplay of factors governing chromosome organization during mitosis.

Main Methods:

  • Utilized advanced fluorescence microscopy.
  • Employed chromosome conformation capture (Hi-C) techniques.
  • Integrated biophysical experiments and computational modeling.

Main Results:

  • Attributed mechanisms to long-observed chromosome structure changes during cell division.
  • Revealed that chromosome organization during cell division is orchestrated by a complex system of factors.
  • Demonstrated that cell division offers a critical window for altering 3D genome organization in daughter cells.

Conclusions:

  • Orchestrating chromosome organization during cell division requires a complex, multifactorial system, not a simple pathway.
  • Cell division is essential for, yet also poses risks to, proper genome organization.
  • Errors in chromosome condensation or post-mitotic rebuilding can lead to diseases like cancer and neurodegeneration.