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Updated: Mar 2, 2026
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The ITS2 Database
Published on: March 12, 2012
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XSuLT: a web server for structural annotation and representation of sequence-structure alignments
Bernardo Ochoa-Montaño1, Tom L Blundell1
1Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.
Nucleic Acids Research
|May 17, 2017
Summary
XSuLT is a web server that enhances protein alignment analysis using 3D structural data. It aids in understanding protein evolution and optimizing alignments for modeling and design.
Area of Science:
- Bioinformatics
- Structural Biology
- Computational Biology
Background:
- Comparative analysis of protein evolution requires accurate sequence alignments.
- Optimization of alignments is crucial for protein modeling and construct design.
- Existing tools may lack comprehensive annotation features.
Purpose of the Study:
- To introduce XSuLT, an enhanced web server for protein alignment annotation.
- To leverage 3D structural information for improved alignment analysis.
- To facilitate comparative analysis of protein evolution and alignment optimization.
Main Methods:
- XSuLT processes multiple-sequence alignments using 3D structural data.
- Annotation includes secondary structure, solvent accessibility, residue depth, and interactions.
- Integrated 3D visualization aids in alignment inspection.
Main Results:
- XSuLT provides enhanced annotation beyond traditional methods.
- Features include residue depth, chain/ligand interactions, and disorder prediction.
- Integrated 3D visualization improves understanding of structural-sequence relationships.
Conclusions:
- XSuLT offers a powerful tool for detailed protein alignment analysis.
- The server aids in comparative evolutionary studies and protein design.
- XSuLT is freely available with downloadable results in HTML and XML formats.
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