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[Cytomegalovirus (CMV): virologic protocols for transplantation]
1Service de Virologie, Hôpital Nord, CHRU, Saint-Etienne.
Nephrologie
|January 1, 1988
Summary
Cytomegalovirus (CMV) infection is common after transplantation. Diagnostic methods include detecting the virus or its antigens via rapid culture and antibody detection using ELISA, aiding in identifying primary infection versus reactivation.
Area of Science:
- Virology
- Immunology
- Transplantation Medicine
Context:
- Cytomegalovirus (CMV) infection poses a significant risk to transplant recipients, manifesting as primary disease or reactivation.
- Monitoring graft recipients for CMV is crucial due to high reactivation rates and potential severity.
Purpose:
- To outline the essential virological procedures for monitoring Cytomegalovirus (CMV) in transplant recipients.
- To detail diagnostic methods for differentiating primary CMV infection from CMV reactivation.
Summary:
- Virological surveillance involves detecting CMV infectious virus or antigens through rapid (24-72h) and classical (2-3 weeks) cultures.
- Antibody detection, including IgM and IgG via ELISA, is key; IgM+/IgG- suggests primary infection, while IgM+/IgG+ or IgM-/IgG+ indicates reactivation.
Impact:
- Provides a framework for timely and accurate CMV diagnosis in immunocompromised patients.
- Facilitates appropriate clinical management decisions for transplant recipients at risk of CMV.
- Highlights the importance of combined viral detection and serological monitoring for effective CMV control.