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The role of the persistent enterovirus infection in development of acute stroke
Natalia G Andriushkova1, Nataliia S Turchyna1, Vadym A Poniatowski1
1O.O. BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE.
Insights
Chronic enterovirus infections are linked to acute stroke. This study found enterovirus genomes and IgG antibodies more frequently in stroke patients, suggesting a trigger role.
Area of Science:
- Virology
- Cardiology
- Neurology
Background:
- Enteroviruses are known to cause heart conditions like myocarditis and cardiomyopathy.
- The potential link between enteroviruses and cerebrovascular diseases remains less understood.
Purpose of the Study:
- To investigate the association between chronic enterovirus infections and the occurrence of acute stroke.
- To determine if enteroviruses play a role in the pathogenesis of acute stroke.
Main Methods:
- Blood samples were collected from 72 acute stroke patients and 35 controls.
- Reverse transcription polymerase chain reaction (RT-PCR) and viral isolation were used to detect enterovirus RNA and viruses.
- Enzyme-linked immunosorbent assay (ELISA) measured IgM and IgG antibody levels against enteroviruses.
Main Results:
- Enterovirus genomes were detected significantly more often in stroke patients (23.6%) compared to controls (2.9%).
- Specific enterovirus types, including Coxsackie B and ECHO viruses, were identified.
- Elevated levels of IgG antibodies to enteroviruses were observed in stroke patients (23.6%) versus controls (5.7%), indicating persistent infection.
Conclusions:
- Enterovirus infections appear to play a triggering role in the development of acute stroke.
- Findings suggest a potential etiological link between enteroviruses and stroke, warranting further investigation.
Introduction:
The role of enteroviruses in development of dilated cardiomyopathy, myocardial infarction, myocarditis, pericarditis is known.
The Aim:
To examine the role of chronic enterovirus infections in development of acute stroke.
Material And Methods:
Blood samples from 72 patients with acute stroke (study group) and 35 patients without vascular disease (control group) were investigated by reverse transcription polymerase chain reaction for the presence of enterovirus RNA, by using virological method to detect enteroviruses, by ELISA for the levels of IgM and IgG antibodies to enteroviruses.
Results:
The enteroviruses genomes were detected significantly often in the serum of patients with stroke (23,6 ± 5,9%) than in control group (2,9 ± 2,8%). The viruses were isolated and were identified as Coxsackie B (serotypes 2, 3, 4) and ECHO (serotypes 6, 9, 27 (two strains), 29), three strains have not been identified in study group. IgM to enteroviruses were not found in the sera of both groups of patients. IgG to enteroviruses were detected in 17 patients in study group (23,6 ± 5,9%) and 2 patients in control group (5,7 ± 3,9%). The presence of enteroviruses genomes and IgG in sera of patients in control group (11,1 ± 3,7%) indicate the persistence of enteroviruses. The proportion of patients with IgG to enteroviruses in sera is higher in study group (12,5 ± 3,9%) than in control group (5,7 ± 3,9%).
Conclusion:
The enterovirus infections play trigger role in development of acute stroke.
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