Features of some clinical examination parameters in patients with psoriatic arthritis

The relationship of cause-and-effect mechanisms of exacerbation and progressing with defining of the role of stress reaction in the psoriatic arthritis (PA) development has been examined in the article by analyzing the characteristics of medical history, current dynamics as well as clinical, instrumental and laboratory examinations. The objective was to study the role of basic indices of laboratory examinations of patients used clarify their role in the pathogenesis of PA.

The concentration of trigger cytokines - IL-1β, IL-8, IL-17, IL-22, stress hormones - ACTH and cortisol, state of cell-antibody mediated immunity (CD3+, CD4+, CD8+, CD16+, CD22+, IRI, IgМ, IgG levels) in the serum of patients were defined.

We have detected the possible changes of stress-reaction mediator concentrations in the serum of patients with PA (i.e. decreasing of the status of cell immunity indices (CD3+, CD4+, CD8+ Т- lymphocytes, В- lymphocytes CD22+ fraction, IRI with compensatory increasing of the levels of CD16+ Т-cells, cytokines - IL-1 β, IL-8, IL-17, IL-22, stress hormone - cortisol, immunoglobulins IgМ, IgG, CIC) irrespective of the disease duration which testifies the strain of their stress-realising mechanisms, even if clinical stabilization of skin and joint process is normalized.

Thus, the final diagnosis of PA is determined only under aggregation of anamnestic, clinical, instrumental and laboratory data and the results of additional examinations. The indices mentioned above are key mediators of stress-realizing immune-neuroendocrine system and play an ambiguous role in the development of PA, their various effects require further study.