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Updated: Sep 3, 2026

RNA-Seq Analysis of Differential Gene Expression in Electroporated Chick Embryonic Spinal Cord
Published on: November 1, 2014
Detection and characterization of the protein encoded by the chicken c-rel protooncogene
1Laboratory of Molecular Virology and Carcinogenesis, BRI-Basic Research Program, NCI-Frederick Cancer Research Facility, MD 21701.
Abstract:
We have identified the protein encoded by chicken c-rel, the cellular homolog of the v-rel oncogene carried by reticuloendotheliosis virus. The protein has been detected in two avian lymphoid cell lines and in chick embryo fibroblasts. It has a molecular weight of 68,000, suggesting that the viral gene (which encodes a protein of 59,000 molecular weight) is a truncated form of its cellular homolog. The c-rel protein is found in the soluble cytoplasmic fraction of chicken lymphoid cells and is not associated in any stable way with other cellular proteins. Unlike the viral protein, p68c-rel is not detectably phosphorylated.
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