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Undifferentiated Uterine Sarcoma: An Uncommon Case Report
Madhumita Mukhopadhyay1, Chhanda Das2, Tamanna Parvin3
1Professor, Department of Pathology, IPGME&R, Kolkata, West Bengal, India.
Endometrial stromal sarcoma, a rare uterine cancer, can present with postmenopausal bleeding. This case highlights an undifferentiated sarcoma with unusual features, emphasizing the importance of thorough histopathological and immunohistochemical analysis for diagnosis.
Area of Science:
- Gynecologic Oncology
- Pathology
- Medical Imaging
Background:
- Endometrial stromal sarcomas (ESS) are rare uterine malignancies originating from the mesodermal layer.
- Postmenopausal bleeding is a significant symptom requiring prompt gynecological evaluation.
Observation:
- A 65-year-old female presented with postmenopausal bleeding.
- Computed Tomography (CT) indicated an enlarged uterus with low attenuation areas.
- Gross examination revealed a distorted endometrial cavity with an irregular, friable, and necrotic mass.
Findings:
- Histopathology confirmed an undifferentiated uterine sarcoma.
- The tumor exhibited rhabdoid, osteoid, and cartilaginous differentiation.
- Presence of osteoclast-like giant cells was noted.
- Immunohistochemistry was strongly positive for CD10.
Implications:
- This case underscores the diverse presentations of uterine sarcomas.
- Accurate diagnosis relies on integrating imaging, gross pathology, histopathology, and immunohistochemistry.
- CD10 positivity can be a key diagnostic marker in challenging ESS cases.
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