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Light Chain Myeloma induced Severe Hypertriglyceridemia.
Shafeeque Rahman1, Prabhat Kumar2, Subodh Kumar Mahto2
1Postgraduate Student Resident, Department of Medicine, PGIMER and Dr Ram Manohar Lohia Hospital, New Delhi, India.
Journal of Clinical and Diagnostic Research : JCDR
|May 18, 2017
Summary
Severe hypertriglyceridemia, a lipid disorder, can be secondary to conditions like Multiple Myeloma (MM). This case highlights light chain myeloma as a cause of severe secondary hypertriglyceridemia and Non-alcoholic Steatohepatitis (NASH).
Area of Science:
- Endocrinology
- Hematology
- Hepatology
Background:
- Hyperlipidemia, particularly elevated triglycerides, is prevalent and requires thorough evaluation for underlying causes and complications.
- Secondary causes of hypertriglyceridemia are numerous, including metabolic disorders, lifestyle factors, and certain medical conditions.
Observation:
- A young female presented with severe secondary hypertriglyceridemia and Non-alcoholic Steatohepatitis (NASH).
- The hypertriglyceridemia was unexpectedly attributed to light chain Multiple Myeloma (MM).
Findings:
- Treatment of the underlying Multiple Myeloma (MM) led to a significant reduction in triglyceride levels.
- This case represents the first documented instance of light chain myeloma causing severe secondary hypertriglyceridemia.
Implications:
- This case underscores the importance of considering hematological malignancies, such as Multiple Myeloma (MM), in the differential diagnosis of severe secondary hypertriglyceridemia.
- Early diagnosis and management of the underlying cause are crucial for preventing complications like Non-alcoholic Steatohepatitis (NASH).
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