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Phytotherapy with Hordeum Vulgare: A Randomized Controlled Trial on Infants with Jaundice
Gholamreza Panahandeh1, Abolfazl Khoshdel2, Morteza Sedehi3
1Assistant Professor, Department of Paediatrics, Shahrekord University of Medical Sciences, Shahrekord, Chaharmahal va Bakhtiari, Iran.
Insights
This study found that topical application of barley (H. vulgare) seed flour, alongside phototherapy, significantly reduced indirect bilirubin levels in jaundiced newborns. Barley flour shows promise as a complementary treatment for neonatal jaundice.
Area of Science:
- Neonatal Medicine
- Pharmacology
- Biochemistry
Background:
- Neonatal jaundice is a frequent cause of hospitalization in newborns.
- Jaundice can lead to severe complications if not managed effectively.
Purpose of the Study:
- To investigate the efficacy of Hordeum vulgare (barley) seed flour in reducing neonatal jaundice.
- To evaluate barley as a complementary therapy for hyperbilirubinemia.
Main Methods:
- A double-blind, randomized controlled trial involving 70 term infants with jaundice.
- Comparison of phototherapy alone (control) versus phototherapy plus topical H. vulgare seed flour (case group).
- Statistical analysis using ANCOVA and paired t-test.
Main Results:
- A significant reduction in mean indirect bilirubin levels was observed in the group treated with H. vulgare (p<0.05).
- No significant difference in direct bilirubin levels was found between the groups at discharge (p>0.05).
Conclusions:
- Hordeum vulgare seed flour effectively decreases indirect bilirubin levels in newborns.
- Barley flour can be utilized as an adjunct therapy to phototherapy for managing jaundice and preventing complications.
Introduction:
Jaundice is one of the most common causes of admission to hospital in newborns which is often associated with several complications.
Aim:
The present study was conducted to evaluate the effect of H. vulgare in reducing jaundice.
Materials And Methods:
In this double-blind, randomized controlled trials 70 term infants hospitalized due to jaundice in 2014 were enrolled. Control group was treated with full-time phototherapy alone using LED except when the infants were breastfed and case group with phototherapy, as per the protocol in the control group, along with and topical H. vulgare seed flour three times a day. Data were analysed using and analysis of covariance (ANCOVA) and paired t-test in SPSS version 16.0.
Results:
There was a significant difference in mean indirect bilirubin level between the two groups p<0.05, such that the mean indirect bilirubin level was higher in the control group. Furthermore, no significant difference was seen in direct bilirubin level between the two groups at discharge p>0.05.
Conclusion:
H. vulgare flour can cause decrease in indirect bilirubin. Because the rate of decrease in indirect bilirubin can be effective in preventing severe complications due to bilirubinemia, H. vulgare can be used as a complementary therapy to treat jaundice.
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