Pancreatic β-cell regeneration: advances in understanding the genes and signaling pathways involved
Solomon Afelik1, Meritxell Rovira2
1Division of Transplantation, Department of Surgery, University of Illinois at Chicago, 840 South Wood Street, CSB 920 (Rm 502), Chicago, IL, 60612, USA. safelik@uic.edu.
Genome Medicine
|May 18, 2017
Abstract:
Recent advances in β-cell regeneration in vivo are providing insights into the mechanisms involved in the conversion of distinct pancreatic cell lineages into β cells. These mechanisms mostly involve reactivation of the gene encoding the pancreatic endocrine cell-specifying transcription factor neurogenin-3.
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