Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serosurvey for polio antibodies.

S Biberi-Moroeanu1, A Munţiu, S Stoiculescu

  • 1National Laboratory for the Control of Sera and Vaccines, Bucharest, Romania.

Virologie
|October 1, 1988
PubMed
Summary

This study assessed polio immunity in 573 individuals, finding high antibody levels against poliovirus types 1, 2, and 3 in vaccinated and historically exposed groups. Results indicate a robust population immunity to poliomyelitis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sequential and combined use of inactivated and oral poliovirus vaccines: Dolj District, Romania, 1992-1994.

The Journal of infectious diseases·1997
Same author

[An immunogenicity and reactogenicity study of a purified, inactivated trivalent influenza vaccine for parenteral administration prepared for the 1996-1997 season].

Bacteriologia, virusologia, parazitologia, epidemiologia (Bucharest, Romania : 1990)·1997
Same author

Paralytic poliomyelitis in Romania, 1984-1992. Evidence for a high risk of vaccine-associated disease and reintroduction of wild-virus infection.

American journal of epidemiology·1994
Same author

Optimum age for measles immunization in Romania.

Virologie·1986
Same author

Use of capillary blood specimens for testing measles HI antibody.

Archives roumaines de pathologie experimentales et de microbiologie·1983
Same author

Measles maternal antibodies in infants.

Archives roumaines de pathologie experimentales et de microbiologie·1983

Area of Science:

  • * Virology and Immunology
  • * Public Health and Epidemiology

Background:

  • * Poliomyelitis remains a significant public health concern, necessitating ongoing monitoring of population immunity.
  • * Understanding polio immunity levels is crucial for assessing the effectiveness of vaccination campaigns and informing public health strategies.

Purpose of the Study:

  • * To evaluate the population's polio immunity status by measuring neutralizing antibodies against poliovirus types 1, 2, and 3.
  • * To compare immunity levels across different age groups and vaccination histories.

Main Methods:

  • * A serological survey conducted from 1982 to 1988 involving 573 participants aged 3-80 years.
  • * Neutralizing antibody testing against Sabin vaccine strains (types 1, 2, 3) and a wild poliovirus type 1 strain.
  • * Participants categorized into four groups based on birth date, vaccination history, and potential exposure to past polio epidemics.

Main Results:

  • * High seropositivity rates observed across all groups: 96.7%-98.9% for type 2, 91.8%-98.2% for type 1 (Sabin), 89.3%-96.6% for type 3, and 84.2%-96.4% for type 1 (wild).
  • * Highest immunity levels were found in fully vaccinated children (Group D) and unvaccinated individuals contemporary to past polio epidemics (Group A).
  • * A notable finding included 14 subjects with adequate antibodies against Sabin strains but seronegative for wild type 1 poliovirus.

Conclusions:

  • * The surveyed population demonstrated a satisfactory level of polio immunity, indicating the success of vaccination programs and/or natural exposure.
  • * The study highlights the importance of considering both vaccination history and potential exposure when assessing population immunity.
  • * Further investigation is warranted for individuals with discordant antibody responses to vaccine and wild poliovirus strains.

Related Experiment Videos