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Anaemia and respiratory failure in a child: can it be idiopathic pulmonary haemosiderosis?
Minhajuddin Ahmed, Dinesh Raj1, Ashwini Kumar1
1Department of Pediatrics, Holy Family Hospital, New Delhi, India.
Insights
This case study highlights pulmonary haemosiderosis, a rare lung condition, in a child presenting with respiratory distress. Diagnosis was confirmed by identifying haemosiderin-laden macrophages in bronchoalveolar lavage fluid.
Area of Science:
- Pediatrics
- Pulmonology
- Hematology
Background:
- Pulmonary haemosiderosis is a rare condition characterized by recurrent pulmonary hemorrhage.
- Early diagnosis and management are crucial for improving patient outcomes.
Observation:
- An 8-year-old male presented with persistent cough, high-grade fever, and acute respiratory distress.
- Clinical findings included anemia, tachypnea, hypoxia, and bilateral lung opacities on chest radiograph.
- A history of blood transfusion during a prior respiratory illness was noted.
Findings:
- Microbiological workup was negative, ruling out infection.
- Bronchoalveolar lavage revealed a significant number of haemosiderin-laden macrophages, confirming the diagnosis of pulmonary haemosiderosis.
- Intravenous pulse methylprednisolone was initiated for treatment.
Implications:
- This case underscores the importance of considering pulmonary haemosiderosis in pediatric patients with unexplained respiratory symptoms and anemia.
- Prompt diagnosis through bronchoalveolar lavage and appropriate treatment can lead to recovery.
- Further research into the underlying causes and long-term management of pediatric pulmonary haemosiderosis is warranted.
Abstract:
We present an 8-year-old male child admitted with cough and high-grade fever for 7 days and respiratory difficulty for 2 days. There was a history of blood transfusion at 2 years of age during a respiratory illness. The child was anaemic, tachycardic, tachypnoeic and hypoxic at presentation. Chest examination revealed equal air entry with fine crackles bilaterally. Blood reports were suggestive of anaemia (haemoglobin 6.5 g/dL), leucocytosis and high C reactive protein levels. Chest radiograph revealed bilateral air space opacities involving diffuse lung fields, right more than left. Relevant microbiological workup was negative. Based on the clinical scenario and investigations, a provisional diagnosis of pulmonary haemosiderosis was kept. The patient was started on intravenous pulse methylprednisolone. Fibre-optic bronchoscopy was done following recovery from the acute event. Bronchoalveolar lavage demonstrated a significant number of haemosiderin-laden macrophages confirming pulmonary haemosiderosis.
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