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Updated: Mar 2, 2026

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats
Published on: April 15, 2016
Oncolytic Virus-Based Immunotherapies for Hepatocellular Carcinoma
So Young Yoo1,2,3,4, Narayanasamy Badrinath1,2, Hyun Young Woo3,4
1BIO-IT Foundry Technology Institute, Pusan National University, Busan 46241, Republic of Korea.
Abstract:
Hepatocellular carcinoma is highly refractory cancer which is resistant to conventional chemotherapy and radiotherapy, carrying a dismal prognosis. Although many anticancer drugs have been developed for treating HCC, sorafenib is the only effective treatment, but it only prolongs survival duration for about 3 months. Recently, oncolytic virotherapy has shown promising results in treating HCCs and the effects can be more enhanced by adopting immune modulatory molecules. This review discusses the current status of treating HCC and the effective strategy of oncolytic virus-based immunotherapy for the treatment of HCCs.
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