Related Experiment Video
Updated: Mar 2, 2026
Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
Published on: April 15, 2022
Immunoglobulin D Multiple Myeloma Presenting as Spontaneous Fracture
Samer Al Hadidi1,2, Khalil Katato2, Ghassan Bachuwa2
1aMichigan State University, Flint, MI, USA.
This case report details a rare Immunoglobulin D multiple myeloma diagnosis in a 53-year-old male presenting with back pain. Successful treatment with chemotherapy and stem cell transplant achieved complete remission.
Area of Science:
- Hematology
- Oncology
Background:
- Multiple myeloma is a plasma cell malignancy.
- Immunoglobulin D multiple myeloma is a rare subtype with distinct clinical and prognostic features.
Observation:
- A 53-year-old male with a history of anaplastic oligodendroglioma presented with back pain due to a T12 pathological fracture.
- Diagnostic workup revealed normocytic anemia, hypercalcemia, elevated serum free kappa light chains, and markedly elevated Immunoglobulin D.
Findings:
- The patient was diagnosed with Immunoglobulin D multiple myeloma.
- Treatment with standard chemotherapy and autologous peripheral blood stem cell transplant resulted in complete remission lasting over 3 years.
Implications:
- This case highlights the importance of considering rare myeloma subtypes in diagnosis.
- Advancements in treatment offer new hope for patients with Immunoglobulin D multiple myeloma, potentially improving outcomes given its historically worse prognosis.
More Related Videos
05:32Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
Published on: January 7, 2019
10:04Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
Related Concept Videos
01:27Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...