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Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
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Relationship between CHOP/GADD153 and unstable human carotid atherosclerotic plaque

Suping Wang1, Meiyan Zhang1, Zanhua Liu1

  • 1a Department of Neurology , Dalian Municipal Central Hospital , Dalian , China.

British Journal of Neurosurgery
|May 18, 2017
PubMed
Abstract

Insights

C/EBP homologous protein (CHOP)/growth-arrest-and-DNA-damage-inducible gene 153 (GADD153) is elevated in unstable atherosclerotic plaques. This finding was independent of other factors that induce endoplasmic reticulum stress, highlighting CHOP/GADD153

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Cellular Stress Response

Background:

  • Endoplasmic reticulum stress (ERS) is linked to apoptosis and the signaling protein C/EBP homologous protein (CHOP)/growth-arrest-and-DNA-damage-inducible gene 153 (GADD153).
  • Atherosclerotic (AS) plaque instability is a critical concern in cardiovascular disease.

Purpose of the Study:

  • To investigate the role of CHOP/GADD153 in unstable AS plaque formation.
  • To isolate the effects of CHOP/GADD153 from confounding factors like diabetes, hypertension, and smoking.

Main Methods:

  • Carotid artery tissue samples from patients undergoing carotid endarterectomy were analyzed.
  • CHOP/GADD153 expression was quantified using immunohistochemistry and RT-PCR.
  • Samples were classified as stable or unstable AS plaques based on histologic criteria.

Main Results:

  • CHOP/GADD153 expression was significantly higher in unstable AS plaques compared to stable plaques (p < .05).
  • Positive immunostaining for CHOP/GADD153 was observed in macrophages and smooth muscle cells within unstable plaques.
  • The study included 32 patients, with 75% having unstable lesions.

Conclusions:

  • CHOP/GADD153 is significantly elevated in unstable atherosclerotic plaques.
  • This elevation is independent of other common inducers of endoplasmic reticulum stress.
  • CHOP/GADD153 may play a crucial role in the pathogenesis of unstable AS plaques.
Keywords:
CHOPGADD153endoplasmic reticulum stressunstable carotid atherosclerotic plaque

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