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ABO blood group is a risk factor for coronary artery disease in patients with poor blood pressure control

Bingyang Zhou1, Naqiong Wu1, Chenggang Zhu1

  • 1a Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|May 18, 2017
PubMed

Insights

Individuals with blood group A have a higher risk of coronary artery disease (CAD) and its severity, particularly when hypertension is poorly controlled. This finding highlights blood group A as a significant risk factor in this patient population.

Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Hypertension Research

Background:

  • Limited research exists on the association between ABO blood groups and coronary artery disease (CAD) in hypertensive individuals with varying blood pressure (BP) control.
  • Hypertension is a major risk factor for CAD, and understanding genetic predispositions like blood groups can refine risk stratification.

Purpose of the Study:

  • To investigate the impact of ABO blood groups on the presence and severity of CAD in patients with primary hypertension.
  • To determine if blood group influences CAD risk and severity, especially in the context of poor blood pressure control.

Main Methods:

  • A cohort of 2708 hypertensive patients undergoing coronary angiography was analyzed.
  • Patients were categorized based on the presence (n=2185) or absence (n=523) of CAD, with severity assessed by Gensini score.
  • Multivariable regression analysis was employed to evaluate the association between ABO blood groups and CAD outcomes.

Main Results:

  • The A blood group was more prevalent, and the O blood group was less prevalent in hypertensive patients with CAD compared to those without CAD.
  • Individuals with blood group A showed a higher incidence of angiography-proven CAD.
  • Blood group A was independently associated with an increased risk of CAD (OR: 1.422) and higher Gensini scores (β = 0.055) in patients with poorly controlled hypertension.

Conclusions:

  • Blood group A is identified as an independent risk factor for both the presence and severity of coronary artery disease in hypertensive patients experiencing poor blood pressure control.
  • These findings suggest that ABO blood group typing may aid in identifying hypertensive individuals at higher risk for CAD, especially when BP management is suboptimal.
Abstract

Keywords:
ABO blood groupGensini scorecoronary artery diseasehypertensionrisk factor

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