T-cell subsets are associated with serum homocysteine concentration in patients with essential hypertension
Huifeng Xu1, Huan Zheng2, Junling Huang2
1a Department of Cardiology , Tongji Hospital of Tongji University , Shanghai , China.
Objective:
To explore the association between serum homocysteine (Hcy) concentration and T-cell subsets from patients with essential hypertension.
Patients And Methods:
A total of 218 essential hypertension patients were recruited, of which 170 were H-type essential hypertensive and 48 were non-H-type essential hypertensive. H-type essential hypertensive patients were divided into three groups by concentration of serum Hcy. The peripheral blood T-cell subsets (CD3+%, CD4+%, CD8+ T%, CD4+/CD8+) and clinical features including age, sex, serum creatinine, uric acid, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were recorded and analyzed with T-cell subsets which were counted by fluorescence activated cytometry.
Results:
Compared with non-H-type hypertensive patients, CD4+ T-cell percentage in peripheral blood was significantly decreased in H-type hypertensive patients. Because of the increase of Hcy level, CD4+ T-cell percentage decreased. Linear regression analysis showed that Hcy level was negatively correlated with CD4+ T-cell percentage; however, it was positively correlated with CD3+ T-cell percentage.
Conclusion:
A direct association between serum Hcy concentrations and T-cell percentage was observed in patients with essential hypertension. This observation indicates that T-cell subsets might play an important role in hypertension.
Related Concept Videos
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Hypertension III: Clinical Manifestations and Diagnostic Studies
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Hypertension II: Pathophysiology
Hypertension and Regulation of Blood Pressure
Hypertension I: Introduction


