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Related Experiment Videos

Calcium supplements: anion effects.

R P Heaney1, R R Recker

  • 1John A. Creighton University, Omaha, NE 68178.

Bone and Mineral
|September 1, 1987
PubMed
Summary
This summary is machine-generated.

This pilot study found that neither carbonate nor phosphate significantly altered bone remodeling in premenopausal women, even at high doses. These findings suggest these common dietary anions are safe and unlikely to impact bone health clinically.

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Area of Science:

  • Biochemistry
  • Bone Biology
  • Nutritional Science

Background:

  • Bone remodeling is a continuous process crucial for skeletal health.
  • Dietary anions like carbonate and phosphate are common in food and supplements.
  • Understanding their impact on bone metabolism is important for public health and therapeutic strategies.

Purpose of the Study:

  • To evaluate the effects of carbonate and phosphate anions on bone remodeling in premenopausal women.
  • To determine if high-dose intake of these anions impacts calcium kinetics and bone biopsy measures.
  • To assess the clinical significance of carbonate and phosphate on human bone remodeling.

Main Methods:

  • Pilot study involving eight premenopausal women under metabolic balance controls.

Related Experiment Videos

  • Paired studies measuring whole-body calcium kinetics and trans-iliac bone biopsies.
  • Treatment with sodium bicarbonate (3240 mg carbonate/day) or phosphate mixture (1144 mg phosphorus/day) for 4 months.

    • Main Results:

    • Phosphate supplementation was well-absorbed and reduced urinary calcium.
    • Both anions showed slight decreases in intestinal calcium absorption efficiency.
    • Neither carbonate nor phosphate significantly altered bone remodeling as measured by radiocalcium kinetics or histomorphometry.

    Conclusions:

    • Neither carbonate nor phosphate anions altered bone remodeling in humans to a clinically significant degree, even at doses exceeding typical dietary intake.
    • Increased phosphorus intake appears safe and does not negatively impact bone remodeling.
    • Findings are relevant to the use of phosphate in osteoporosis treatment approaches like ADFR (coherence therapy).