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Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
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hCG Triggering in ART: An Evolutionary Concept.

Anat Hershko Klement1,2, Adrian Shulman3,4

  • 1Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba 4428164, Israel. anat.klement@gmail.com.

International Journal of Molecular Sciences
|May 18, 2017
PubMed
Summary
This summary is machine-generated.

Human chorionic gonadotropin (hCG) is evolving as an ovulation trigger. Combining gonadotropin-releasing hormone (GnRH) agonist with hCG enhances ovum maturation and supports early pregnancy.

Keywords:
LH receptorchorionic gonadotropinovarian stimulationovulation induction

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Area of Science:

  • Reproductive Endocrinology
  • Infertility Treatments

Background:

  • Human chorionic gonadotropin (hCG) has been the standard for ovulation induction.
  • Newer protocols explore alternative and adjunctive agents for improved outcomes.

Purpose of the Study:

  • To evaluate the evolving role of ovulation triggering agents.
  • To explore the combined use of GnRH agonist and hCG in assisted reproductive technologies.

Main Methods:

  • Review of current literature on ovulation induction protocols.
  • Analysis of the physiological roles of GnRH agonist and hCG.

Main Results:

  • GnRH agonist administration prior to hCG represents a novel triggering strategy.
  • This dual-trigger approach facilitates oocyte maturation and supports the luteal phase.

Conclusions:

  • The combination of GnRH agonist and hCG offers a new paradigm in ovulation triggering.
  • This strategy may enhance pregnancy success rates by optimizing both maturation and luteal support.