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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Kidney Transplant III: Nursing Management01:16

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Kidney Transplant II: Surgical Procedure01:26

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Tissue Transplantation01:24

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Related Experiment Video

Updated: Mar 2, 2026

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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Epstein-Barr virus encephalitis in solid organ transplantation.

Jillian S Y Lau1, Zhi Mei Low1, Iain Abbott2

  • 1Monash Infectious Diseases, Monash Health, Clayton, VIC, Australia.

The New Microbiologica
|May 18, 2017
PubMed
Summary

Severe Epstein-Barr virus (EBV) encephalitis occurred six months post-renal transplant. Prompt treatment, including reduced immunosuppression and antivirals, led to full recovery and graft survival.

Keywords:
EncephalitisEpstein-Barr virusImmunosuppressionTransplant

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Area of Science:

  • Infectious Diseases
  • Neurology
  • Transplantation Immunology

Background:

  • Epstein-Barr virus (EBV) commonly causes post-transplant lymphoproliferative disease (PTLD) but rarely neurological complications.
  • Primary EBV infection post-solid organ transplantation necessitates understanding its diverse clinical manifestations.

Observation:

  • A 55-year-old male renal transplant recipient developed severe encephalitis six months post-transplant, presenting with headache, fever, and confusion.
  • Cerebrospinal fluid and plasma EBV DNA levels were significantly elevated, confirming active viral replication.
  • Electroencephalogram indicated diffuse encephalopathy, despite unremarkable neuroimaging.

Findings:

  • Management involved reducing immunosuppression, administering intravenous ganciclovir and intravenous immunoglobulin (IVIg).
  • This therapeutic approach successfully decreased EBV viral loads in both cerebrospinal fluid and plasma.
  • The patient achieved a complete neurological recovery with preserved renal graft function.

Implications:

  • Highlights the critical importance of assessing EBV serostatus in donors and recipients pre-transplant.
  • Emphasizes the need for vigilant EBV DNA monitoring in seromismatched transplant recipients.
  • Suggests prophylactic ganciclovir/valganciclovir and prompt treatment strategies for EBV encephalitis post-transplant.