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Updated: Mar 2, 2026

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
Published on: August 20, 2018
Hydrophobic α,α-Disubstituted Disilylated TESDpg Induces Incipient 310-Helix in Short Tripeptide Sequence
Roberto Fanelli1, Dorothée Berthomieu2, Claude Didierjean3
1Institut des Biomolécules Max Mousseron, IBMM, UMR-5247, CNRS, Université Montpellier , ENSCM, Place Eugène Bataillon, Montpellier 34095 Cedex 5, France.
Abstract:
To evaluate the contribution of triethylsilyl α,α-di-n-propylglycine, namely TESDpg, to induce a defined secondary structure, we have prepared model tripeptides in which TESDpg was inserted in three different positions. Studies in solid state and in solution with adapted techniques showed that TESDpg was able to induce a nascent 310 helix in both crystal and solution states.
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