Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

397
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
397
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

287
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
287
Determination of Renal Drug Clearance: Graphical and Midpoint Methods01:07

Determination of Renal Drug Clearance: Graphical and Midpoint Methods

448
Renal clearance, a crucial parameter in pharmacokinetics, can be determined using two different methods: the graphical method and the midpoint method. These methods provide insights into the rate of drug excretion by the kidneys and aid in assessing renal function.
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
448
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

544
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
544
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

599
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
599
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

75
The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
75

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Towards optimal valve prescription for transcatheter aortic valve replacement (TAVR) surgery: a machine learning approach.

Health care management science·2026
Same author

Elevations in Donor-Derived Cell-Free DNA and Allograft Outcomes in Kidney Transplantation.

Journal of the American Society of Nephrology : JASN·2026
Same author

Quantifying long-term outcomes and risks for living liver donors: a review of the current global experience.

Annals of hepatology·2026
Same author

Missed Opportunities in Donation After Circulatory Death Liver Transplantation: A National Analysis of Non-Allocation and Non-Procurement.

Clinical transplantation·2026
Same author

Beyond survival: Creation of a novel composite index to assess value-based care in liver transplantation.

Surgery·2026
Same author

Psychiatric Disease and Medical Financial Burden Among Commercially Insured Adult Kidney Transplant Recipients in the United States.

Clinical transplantation·2026

Related Experiment Video

Updated: Mar 2, 2026

Using a Chemical Biopsy for Graft Quality Assessment
05:00

Using a Chemical Biopsy for Graft Quality Assessment

Published on: June 17, 2020

5.7K

Accept or Decline? An Analytics-Based Decision Tool for Kidney Offer Evaluation.

Dimitris Bertsimas1, Jerry Kung1, Nikolaos Trichakis1

  • 1Operations Research Center, Massachusetts Institute of Technology, Cambridge, MA.

Transplantation
|May 18, 2017
PubMed
Summary
This summary is machine-generated.

A new data-driven model predicts kidney offers, moving beyond intuition to improve transplant decisions. This analytics-based approach aids patients and practitioners in choosing the best kidney offers for timely transplantation.

More Related Videos

TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients
09:00

TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients

Published on: April 13, 2021

5.5K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.8K

Related Experiment Videos

Last Updated: Mar 2, 2026

Using a Chemical Biopsy for Graft Quality Assessment
05:00

Using a Chemical Biopsy for Graft Quality Assessment

Published on: June 17, 2020

5.7K
TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients
09:00

TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients

Published on: April 13, 2021

5.5K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.8K

Area of Science:

  • Nephrology
  • Transplant Surgery
  • Data Science in Healthcare

Background:

  • Kidney transplant decisions often rely on practitioner experience, balancing immediate benefits against future offers.
  • Current methods lack scientific rigor, leading to potential inaccuracies in organ offer acceptance.

Purpose of the Study:

  • To develop a data-driven model for predicting deceased-donor kidney offers.
  • To assist transplant practitioners and candidates in making informed decisions about organ acceptance.

Main Methods:

  • A predictive model was created using historical data, including Organ Procurement Organization, blood group, wait time, and prior offer history.
  • The model predicts the likelihood of receiving a kidney offer at specific Kidney Donor Profile Index thresholds and timeframes.

Main Results:

  • The model achieved an out-of-sample area under the receiver operating characteristic curve of approximately 0.87.
  • Performance was consistent across various Kidney Donor Profile Index thresholds and timeframes for major Organ Procurement Organizations.

Conclusions:

  • A data-driven model can enhance the decision-making process for kidney offers.
  • This approach promises to facilitate timely transplantation and optimize organ allocation efficiency.