Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Photosystem I01:27

Photosystem I

70.6K
Although structurally similar to photosystem II (PSII), photosystem I (PSI) is has a different electron supplier and electron acceptor.
Both these photosystems work in concert. An excited electron from PSII is relayed to PSI via an electron transport chain in the thylakoid membrane of the chloroplast, which is comprised of the carrier molecule plastoquinone, the dual-protein cytochrome complex, and plastocyanin. As electrons move between PSII and PSI, they lose energy and must be re-energized...
70.6K
The Photochemical Reaction Center01:29

The Photochemical Reaction Center

5.7K
Reaction centers are pigment-protein complexes that initiate energy conversion from photons to chemical entities. Therefore, photochemical reaction center is a more appropriate term that describes these complexes. The Nobel laureates Robert Emerson and William Arnold provided the first experimental evidence of photochemical reaction centers by demonstrating the participation of nearly 2,500 chlorophyll molecules for the release of just one molecule of oxygen. Despite thousands of photosynthetic...
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Small-molecule modulators of HIPK4 activity and proteostasis.

bioRxiv : the preprint server for biology·2026
Same author

Evaluation of Benzo[cd]indol-2(1H)-ones as Downstream Hedgehog Pathway Inhibitors.

ChemistryOpen·2025
Same author

Author Correction: Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1.

Nature chemical biology·2024
Same author

Catalytic asymmetric synthesis of meta benzene isosteres.

Nature·2024
Same author

Antisense Oligonucleotide Activation via Enzymatic Antibiotic Resistance Mechanism.

ACS chemical biology·2023
Same author

Bicyclic Caged Morpholino Oligonucleotides for Optical Gene Silencing.

Chembiochem : a European journal of chemical biology·2022

Related Experiment Video

Updated: Mar 2, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

7.5K

Illuminating developmental biology through photochemistry.

Lukasz Kowalik1,2, James K Chen1,3

  • 1Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California, USA.

Nature Chemical Biology
|May 18, 2017
PubMed
Summary

Photoactivatable probes offer precise control over biological molecules and cells, advancing developmental biology. These optochemical and optogenetic tools are crucial for understanding complex organismal development mechanisms.

More Related Videos

Bioluminescent Optogenetics 2.0: Harnessing Bioluminescence to Activate Photosensory Proteins In Vitro and In Vivo
07:19

Bioluminescent Optogenetics 2.0: Harnessing Bioluminescence to Activate Photosensory Proteins In Vitro and In Vivo

Published on: August 4, 2021

5.4K
Two-Photon-Based Photoactivation in Live Zebrafish Embryos
09:10

Two-Photon-Based Photoactivation in Live Zebrafish Embryos

Published on: December 24, 2010

12.1K

Related Experiment Videos

Last Updated: Mar 2, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

7.5K
Bioluminescent Optogenetics 2.0: Harnessing Bioluminescence to Activate Photosensory Proteins In Vitro and In Vivo
07:19

Bioluminescent Optogenetics 2.0: Harnessing Bioluminescence to Activate Photosensory Proteins In Vitro and In Vivo

Published on: August 4, 2021

5.4K
Two-Photon-Based Photoactivation in Live Zebrafish Embryos
09:10

Two-Photon-Based Photoactivation in Live Zebrafish Embryos

Published on: December 24, 2010

12.1K

Area of Science:

  • Developmental biology
  • Chemical biology
  • Molecular and cellular mechanisms

Background:

  • Developmental biology has evolved from descriptive to mechanistic, driven by technological advances like genome sequencing and omics profiling.
  • Translating vast genetic and biochemical data into functional understanding requires novel experimental tools.

Purpose of the Study:

  • To review the application of photoactivatable probes in developmental biology.
  • To highlight insights gained from optochemical and optogenetic systems in multicellular organisms.
  • To discuss limitations and future directions for photoactivatable technologies.

Main Methods:

  • Focuses on optochemical and optogenetic systems.
  • Describes applications in multicellular organisms.
  • Reviews insights and limitations of photoactivatable probes.

Main Results:

  • Photoactivatable probes enable spatiotemporal control over DNA, RNA, proteins, and cells.
  • These tools provide valuable insights into developmental mechanisms.
  • Current limitations and future potential for chemical biologists are discussed.

Conclusions:

  • Photoactivatable probes are essential for advancing functional understanding in developmental biology.
  • Expanding these technologies will deepen insights into organismal development.
  • Chemical biologists play a key role in developing and applying these advanced tools.