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A Retrosynthesis Approach for Biocatalysis in Organic Synthesis
Rodrigo O M A de Souza1, Leandro S M Miranda1, Uwe T Bornscheuer2
1Biocatalysis and Organic Synthesis Group, Federal University of Rio de Janeiro, Chemistry Institute, 21941909, Rio de Janeiro, Brazil.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|May 18, 2017
Summary
This review explores enzyme-catalyzed functional group interconversions for organic synthesis, organizing reactions by chemical bonds formed (C-N, C-O, C-C) to aid chemists in designing biocatalytic routes.
Area of Science:
- Organic Chemistry
- Biocatalysis
- Synthetic Chemistry
Background:
- Retrosynthetic analysis is established for organic synthesis planning.
- Biocatalytic route planning concepts are still developing.
- Enzyme-catalyzed functional group interconversions are key for biocatalysis.
Purpose of the Study:
- To review enzyme-catalyzed functional group interconversions.
- To organize biocatalytic reactions by chemical bond formation (C-N, C-O, C-C).
- To provide guidelines for selecting enzymes in organic synthesis.
Main Methods:
- Highlighting enzyme-catalyzed functional group interconversions.
- Organizing reactions by chemical bonds formed (C-N, C-O, C-C).
- Exemplifying biocatalyst use in synthesizing drugs and pharmaceutical intermediates.
Main Results:
- Demonstrated biocatalytic approaches for C-N, C-O, and C-C bond formation.
- Showcased successful applications in synthesizing Crispine A, Sitagliptin, and Atorvastatin.
- Provided practical guidelines for enzyme selection in synthesis.
Conclusions:
- Enzymes offer powerful tools for functional group interconversions in organic synthesis.
- Biocatalysis, combined with chemical steps, is effective for drug and intermediate synthesis.
- Guidelines assist chemists in integrating biocatalysts into synthetic strategies.
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