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Updated: Mar 2, 2026
Isolation of Primary Mouse Retinal Pigmented Epithelium Cells
Published on: November 4, 2022
[Age-related changes in biogenic amine content and oxidative stress profile in the rat hypothalamus in
Yu P Milyutina1, A V Pustygina1, I V Zaloznyaya1
1D.O.Ott Institute of Obstetrics, Gynecology and Reproductology, Saint-Petersburg, 199034, Russian Federation; milyutina1010@mail.ru.
Abstract:
The article presents a detailed analysis of correlations between the content of a variety of biogenic amines in the hypothalamic structures responsible for the luteinizing hormone releasing hormone synthesis and secretion (the medial preoptic area and median eminence) and such independent factors as total L-homocysteine plasma level elevation induced by L-methionine loading and aging. Both a nature and a pattern of changes in oxidative stress profile were evaluated. It was shown that ageing, when compared to hyperhomocysteinemia, is a determining factor influencing biogenic amine content in the studied hypothalamic structures. Unlike antioxidant defense system profile, considerable changes in macromolecule oxidative modification were not found, which evidences a balanced activity of pro- and antioxidant systems in the hypothalamus.
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