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[The changes in hormonal status of the cardiovascular and the thyroid systems in rats with 18-month type 2 diabetes

K V Derkach1, P A Ignatieva2, I V Bogush1

  • 1I.M.Sechenov Institute of Evolutionary Physiology and Biochemistry, RAS, Saint-Petersburg, 194223, Russian Federation.

Advances in Gerontology = Uspekhi Gerontologii
|May 18, 2017
PubMed

Insights

Type 2 diabetes mellitus (DM2) impairs cardiovascular and thyroid function, particularly with age. This study reveals age-related adenylyl cyclase signaling system (ACSS) dysfunction in diabetic rat hearts and thyroids, contributing to hypothyroid states.

Area of Science:

  • Endocrinology
  • Cardiovascular Physiology
  • Molecular Signaling

Background:

  • Type 2 diabetes mellitus (DM2) commonly leads to cardiovascular and thyroid complications.
  • Aging exacerbates these complications, but the underlying molecular mechanisms, including adenylyl cyclase signaling system (ACSS) alterations, are not fully understood.

Purpose of the Study:

  • To investigate thyroid status and ACSS activity in the myocardium and thyroid gland (TG) of rats with 8- and 18-month DM2.
  • To compare these findings with age-matched control groups.

Main Methods:

  • Assessment of thyroid hormones (free thyroxine, total triiodothyronine, TSH) and ACSS activity.
  • Comparison between diabetic (DM-8, DM-18) and control (C-8, C-18) rat groups.

Main Results:

  • DM2 rats exhibited myocardial ACSS dysregulation, worsening with age.
  • Diabetic rats showed decreased free thyroxine and total triiodothyronine, increased TSH, and reduced TSH stimulation of ACSS in TG, indicating hypothyroidism.
  • Age-matched controls (C-18) showed less pronounced ACSS disturbances.

Conclusions:

  • Hormonal regulation of ACSS is impaired in the myocardium and TG of rats with long-term DM2 (18 months).
  • This ACSS dysfunction may contribute to cardiovascular pathology and hypothyroidism in advanced type 2 diabetes.
Keywords:
adenylyl cyclaseadrenergic agonistage-related changesdiabetes mellitusmyocardiumthyroid gland

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