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Advancing Histocompatibility Testing for Solid Organ Transplantation - What is Needed? A Personal Opinion
Matthew F Cusick1, Anat R Tambur1
1Transplant Immunology Laboratory, Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Clinical Transplants
|May 18, 2017
Summary
Histocompatibility testing has advanced significantly with polymerase chain reaction amplification for human leukocyte antigen (HLA) typing and solid phase assays for antibody detection, improving transplant outcomes.
Area of Science:
- Immunogenetics
- Transplantation immunology
Background:
- Histocompatibility testing has evolved over the last 25 years.
- Key advancements include polymerase chain reaction (PCR) amplification and solid phase antibody testing.
Purpose of the Study:
- To provide an overview of current advancements in histocompatibility testing.
- To offer insights into future directions and ongoing progress in the field.
Main Methods:
- Review of advancements in human leukocyte antigen (HLA) typing using PCR.
- Analysis of solid phase assays for antibody specificity and rejection monitoring.
Main Results:
- PCR amplification has revealed extensive polymorphism in HLA alleles.
- Solid phase testing offers detailed antibody specificity and insights into antibody-mediated rejection.
Conclusions:
- Significant progress in histocompatibility testing has enhanced understanding of HLA polymorphism and antibody-mediated rejection.
- The field is poised for further innovation in transplantation immunology.
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