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Clinical Positioning Accuracy for Multisession Stereotactic Radiotherapy With the Gamma Knife Perfexion
Wade P Smith1,2, Lori A Young1, Mark H Phillips1,2
1Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA, USA.
Technology in Cancer Research & Treatment
|May 19, 2017
Summary
The Elekta Extend system significantly improves the precision of multisession stereotactic radiation therapy for brain lesions. This advanced system reduces daily setup uncertainty, enhancing treatment accuracy for complex intracranial cases.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Medical Physics
Background:
- Multisession stereotactic radiation therapy is a preferred treatment for intracranial diseases near critical structures or with large target volumes.
- Ensuring precision in fractionated treatments is crucial for patient outcomes.
Purpose of the Study:
- To evaluate the reproducibility and setup uncertainty of the Elekta Extend system for multisession stereotactic radiotherapy.
- To compare the Extend system's performance against a previously used linac-based approach.
Main Methods:
- Retrospective review of 84 patients treated with multisession Gamma Knife (July 2010 - June 2015).
- Analysis of residual daily setup uncertainty measurements from the Extend system.
- Comparison with historical data from a linac-based stereotactic radiotherapy system.
Main Results:
- The Extend system demonstrated an average residual daily setup uncertainty of 0.48 (0.19) mm.
- Significant reduction in setup uncertainty compared to the previous linac-based method.
- Positive outcomes noted in a subset of edentulous patients.
Conclusions:
- The Elekta Extend system offers a robust, precise, and user-friendly method for multisession intracranial stereotactic radiotherapy.
- The system significantly enhances precision for fractionated intracranial treatments.
- It compares favorably to other intracranial stereotactic radiotherapy delivery methods.
