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Related Experiment Video

Updated: Mar 2, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Reverse atrial electrical remodeling induced by cardiac resynchronization therapy.

Bryce Alexander1, Fariha Sadiq1, Kousha Azimi1

  • 1Division of Cardiology, Queen's University, Kingston, Ontario, Canada.

Journal of Electrocardiology
|May 19, 2017
PubMed
Summary

Cardiac resynchronization therapy (CRT) shortens P-wave duration, indicating reverse electrical remodeling in the atria. Further research is needed to confirm its impact on atrial fibrillation incidence.

Keywords:
Atrial remodelingCardiac resynchronization therapyInteratrial block

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Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Devices

Background:

  • Cardiac resynchronization therapy (CRT) improves cardiac function.
  • The impact of CRT on atrial electrical remodeling is not well understood.
  • Atrial electrical remodeling can affect cardiac function and rhythm.

Purpose of the Study:

  • To investigate the effect of CRT on reverse atrial electrical remodeling.
  • To assess if CRT leads to a reduction in P-wave duration on surface ECG.
  • To evaluate the potential link between CRT and changes in atrial electrical properties.

Main Methods:

  • Analysis of 41 patients receiving CRT with >92% biventricular pacing.
  • Exclusion of patients with a history of atrial fibrillation (AF).
  • Measurement of P-wave duration and advanced interatrial block (aIAB) via ECG before and after CRT implantation.

Main Results:

  • Significant reduction in P-wave duration (142.7 ms to 133.1 ms; p < 0.001) after CRT.
  • Significant decrease in advanced interatrial block (36% to 17%; p = 0.03).
  • New onset AF incidence was 36%, not influenced by P-wave duration changes.

Conclusions:

  • CRT promotes atrial reverse electrical remodeling, evidenced by shorter P-wave duration.
  • Larger studies are required to determine the clinical significance of these findings on AF incidence.