Related Experiment Video

Updated: Mar 2, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

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Incorporating New Systemic Therapies in Kidney Cancer Treatment

Eric Jonasch1

  • 1Presented by Eric Jonasch, MD, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Journal of the National Comprehensive Cancer Network : JNCCN
|May 19, 2017
PubMed

Insights

Pazopanib and sunitinib are standard for advanced renal cell carcinoma. Cabozantinib may change frontline care for intermediate/poor risk patients, with other agents offering second-line survival benefits.

Area of Science:

  • Oncology
  • Medical Research

Background:

  • Pazopanib and sunitinib are current first-line treatments for advanced renal cell carcinoma.
  • The evolving landscape of renal cell carcinoma treatment necessitates updated therapeutic strategies.

Purpose of the Study:

  • To evaluate the potential impact of cabozantinib on the standard of care for frontline advanced renal cell carcinoma treatment.
  • To review second-line treatment options demonstrating survival advantages.

Main Methods:

  • Review of current clinical practice and emerging therapeutic data for advanced renal cell carcinoma.
  • Analysis of survival data for various systemic agents in first- and second-line settings.

Main Results:

  • Cabozantinib shows potential to alter frontline therapy for intermediate and poor-risk advanced renal cell carcinoma patients.
  • Nivolumab, cabozantinib, and lenvatinib plus everolimus combination demonstrate survival benefits in the second-line setting.

Conclusions:

  • Frontline treatment for advanced renal cell carcinoma may shift with the introduction of cabozantinib.
  • Second-line treatment selection requires consideration of patient-specific factors and available resources.

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