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Novel Treatment Options for Neuroendocrine Tumors

Matthew H Kulke1

  • 1Presented by Matthew H. Kulke, MD, MMSc, Dana-Farber Cancer Institute, Boston, Massachusetts.

Journal of the National Comprehensive Cancer Network : JNCCN
|May 19, 2017
PubMed

Insights

Neuroendocrine tumors (NETs) are increasingly prevalent gastrointestinal cancers. Somatostatin analogues are a primary treatment for metastatic NETs, with alternatives used if they prove ineffective.

Area of Science:

  • Gastroenterology
  • Oncology
  • Endocrinology

Background:

  • Neuroendocrine tumors (NETs) are a diverse group of neoplasms.
  • NET prevalence is higher than previously estimated, impacting gastrointestinal oncology.
  • Treatment strategies for NETs depend on tumor histology and origin.

Purpose of the Study:

  • To review the current understanding of neuroendocrine tumor prevalence.
  • To outline available treatment options for NETs.
  • To discuss the role of somatostatin analogues in metastatic NET management.

Main Methods:

  • Literature review of neuroendocrine tumor epidemiology.
  • Analysis of current therapeutic guidelines for NETs.
  • Evaluation of treatment sequencing for metastatic disease.

Main Results:

  • NETs are more common than previously recognized.
  • A range of treatments exist for NETs, tailored to specific tumor characteristics.
  • Somatostatin analogues are a standard first-line therapy for metastatic NETs.

Conclusions:

  • Neuroendocrine tumors require careful diagnostic and therapeutic consideration.
  • Treatment selection for NETs is individualized based on tumor factors.
  • Further research into novel therapeutic agents for refractory NETs is warranted.

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