Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultra-early neurological pupil index trajectories and clinical outcomes in acute brain injury.

Frontiers in neurology·2026
Same author

Endothelial oncogenic KRAS mutation drives the dynamics of microglia and macrophages in brain arteriovenous malformation.

JCI insight·2026
Same author

Early peripheral blood gene expression predicts 90-day outcomes following subarachnoid hemorrhage.

Journal of neuroinflammation·2025
Same author

Targeted proteomic analysis identifies ACVRL1 as a marker of cerebral edema in aneurysmal subarachnoid hemorrhage.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2025
Same author

Epidemiological Patterns and Variability in Acute Brain Injury: A Multicenter Registry Analysis in South Korea's Neurocritical Care Units.

Neurocritical care·2025
Same author

In-Hospital Mortality and Hemorrhagic Risks in Traumatic Brain Injury Patients with Early vs. Late Venous Thromboembolism.

TH open : companion journal to thrombosis and haemostasis·2025

Related Experiment Video

Updated: Mar 2, 2026

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

16.8K

Hung over? Maybe it's your overactive microglia.

Huimahn Alex Choi1

  • 1Department of Neurosurgery and Neurology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 77030, USA.

Science Translational Medicine
|May 19, 2017
PubMed
Summary
This summary is machine-generated.

Acute alcohol consumption temporarily reduces microglial cell activity. Following alcohol withdrawal, a significant inflammatory response in microglia is observed.

More Related Videos

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

10.4K
Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity
08:37

Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity

Published on: October 25, 2016

7.5K

Related Experiment Videos

Last Updated: Mar 2, 2026

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

16.8K
Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

10.4K
Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity
08:37

Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity

Published on: October 25, 2016

7.5K

Area of Science:

  • Neuroscience
  • Immunology
  • Toxicology

Background:

  • Microglia are the primary immune cells of the central nervous system.
  • Ethanol (alcohol) is a widely consumed psychoactive substance with known neuroinflammatory effects.
  • Understanding the dynamic changes in microglial activity during alcohol exposure and withdrawal is crucial for neuroprotection.

Purpose of the Study:

  • To investigate the impact of acute ethanol intake on microglial activity.
  • To characterize the inflammatory response of microglia during the alcohol withdrawal period.

Main Methods:

  • Utilizing in vivo models to assess microglial activation markers.
  • Quantifying inflammatory mediators released by microglia following ethanol exposure and withdrawal.

Main Results:

  • Acute ethanol intake led to a transient, mild suppression of microglial activity.
  • The alcohol withdrawal phase was characterized by a pronounced and sustained inflammatory reaction in microglia.
  • Elevated levels of pro-inflammatory cytokines were detected during withdrawal.

Conclusions:

  • Ethanol modulates microglial function in a biphasic manner: initial suppression followed by heightened inflammation.
  • Alcohol withdrawal syndrome is associated with significant neuroinflammation driven by microglial activation.
  • These findings highlight microglia as key players in alcohol-induced neuroinflammation and suggest potential therapeutic targets during withdrawal.