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Mesenchymal stem cell therapy in type 2 diabetes mellitus
Li Zang1, Haojie Hao2, Jiejie Liu2
1Department of Endocrinology, Chinese PLA General Hospital, Beijing, 100853 China.
Diabetology & Metabolic Syndrome
|May 19, 2017
Summary
Mesenchymal stem cells (MSCs) show promise for treating type 2 diabetes mellitus (T2DM) by improving glycemic control. However, further large-scale clinical trials are needed to establish MSC transplantation as a standard therapy for T2DM.
Area of Science:
- Regenerative Medicine
- Endocrinology
- Immunology
Background:
- Type 2 diabetes mellitus (T2DM) involves insulin deficiency and resistance, lacking curative treatments.
- Insulin-producing cell (IPC) transplantation, a potential diabetes therapy, faces clinical translation challenges.
- Mesenchymal stem cells (MSCs) possess differentiation, immunosuppressive, and anti-inflammatory properties, making them candidates for T2DM treatment.
Purpose of the Study:
- To review the molecular mechanisms of MSC treatment for T2DM.
- To evaluate the benefits and drawbacks of current MSC clinical trials for T2DM.
Main Methods:
- Review of existing literature on MSCs and T2DM.
- Analysis of in vitro and in vivo studies demonstrating MSC therapeutic effects.
- Examination of outcomes from current clinical trials involving MSC transplantation for T2DM.
Main Results:
- MSC research shows significant potential for improving glycemic control in T2DM.
- Current clinical trials indicate promising therapeutic effects of MSCs.
- Identified challenges and potential problems in existing clinical trials.
Conclusions:
- MSCs offer a promising cell-based therapy for T2DM due to their multifaceted properties.
- Rigorous, multi-center, large-scale, double-blind, placebo-controlled studies are essential.
- Further research and strict supervision are required before MSC transplantation becomes a routine T2DM treatment.
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