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Mesenchymal stem cell therapy in type 2 diabetes mellitus

Li Zang1, Haojie Hao2, Jiejie Liu2

  • 1Department of Endocrinology, Chinese PLA General Hospital, Beijing, 100853 China.

Diabetology & Metabolic Syndrome
|May 19, 2017
PubMed

Insights

Mesenchymal stem cells (MSCs) show promise for treating type 2 diabetes mellitus (T2DM) by improving glycemic control. However, further large-scale clinical trials are needed to establish MSC transplantation as a standard therapy for T2DM.

Area of Science:

  • Regenerative Medicine
  • Endocrinology
  • Immunology

Background:

  • Type 2 diabetes mellitus (T2DM) involves insulin deficiency and resistance, lacking curative treatments.
  • Insulin-producing cell (IPC) transplantation, a potential diabetes therapy, faces clinical translation challenges.
  • Mesenchymal stem cells (MSCs) possess differentiation, immunosuppressive, and anti-inflammatory properties, making them candidates for T2DM treatment.

Purpose of the Study:

  • To review the molecular mechanisms of MSC treatment for T2DM.
  • To evaluate the benefits and drawbacks of current MSC clinical trials for T2DM.

Main Methods:

  • Review of existing literature on MSCs and T2DM.
  • Analysis of in vitro and in vivo studies demonstrating MSC therapeutic effects.
  • Examination of outcomes from current clinical trials involving MSC transplantation for T2DM.

Main Results:

  • MSC research shows significant potential for improving glycemic control in T2DM.
  • Current clinical trials indicate promising therapeutic effects of MSCs.
  • Identified challenges and potential problems in existing clinical trials.

Conclusions:

  • MSCs offer a promising cell-based therapy for T2DM due to their multifaceted properties.
  • Rigorous, multi-center, large-scale, double-blind, placebo-controlled studies are essential.
  • Further research and strict supervision are required before MSC transplantation becomes a routine T2DM treatment.
Keywords:
Insulin resistanceMesenchymal stem cellsType 2 diabetes mellitus

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