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Lupus-Negative Libman-Sacks Endocarditis Complicated by Catastrophic Antiphospholipid Syndrome
Ghulam Murtaza1, Joy Iskandar1, Tara Humphrey1
1Department of Internal Medicine, Advocate Christ Medical Center, Oak Lawn, IL, USA.
Libman-Sacks endocarditis, linked to antiphospholipid antibody syndrome (APS), can rarely manifest as catastrophic APS (CAPS). This case highlights a young, lupus-negative patient experiencing this severe complication.
Area of Science:
- Cardiology
- Rheumatology
- Hematology
Background:
- Libman-Sacks endocarditis involves sterile, verrucous lesions on heart valves, often without significant dysfunction.
- Complications like cardiac failure and thromboembolism can arise with severe valvular dysfunction.
- Antiphospholipid antibody syndrome (APS) is associated with thrombosis, pregnancy loss, and thrombocytopenia, often secondary to systemic lupus erythematosus.
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