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Published on: August 8, 2025
Contrast use in relation to the arterial access site for percutaneous coronary intervention: A comprehensive
Rahman Shah1, Anthony Mattox1, M Rehan Khan1
1Rahman Shah, Anthony Mattox, Section of Cardiovascular Medicine, School of Medicine, University of Tennessee, Memphis, TN 38104, United States.
Insights
This meta-analysis found no significant difference in contrast volume used for percutaneous coronary intervention (PCI) via trans-radial access (TRA) versus trans-femoral access (TFA). Both methods are comparable in terms of contrast utilization.
Area of Science:
- Cardiology
- Interventional Cardiology
- Medical Imaging
Background:
- Percutaneous coronary intervention (PCI) is a common procedure for treating coronary artery disease.
- Trans-radial access (TRA) and trans-femoral access (TFA) are two primary vascular access routes for PCI.
- The volume of contrast media used can impact patient outcomes and procedure costs.
Purpose of the Study:
- To compare the amount of contrast media utilized during PCI procedures performed via trans-radial access (TRA) versus trans-femoral access (TFA).
Main Methods:
- A systematic literature search was conducted across scientific databases and websites.
- Randomized controlled trials (RCTs) comparing contrast volume in TRA versus TFA for PCI were included.
- Data were extracted by two independent reviewers, and a meta-analysis was performed using a random-effects model to calculate the weighted mean difference (WMD) with 95% confidence intervals (CI).
Main Results:
- The meta-analysis included 13 RCTs encompassing 3165 patients.
- No statistically significant difference was observed in the amount of contrast media used between the TRA and TFA groups (WMD = -0.65 mL, 95% CI: -10.94-9.46 mL, P = 0.901).
Conclusions:
- In patients undergoing PCI, the volume of contrast media used is not significantly different between trans-radial access and trans-femoral access.
- This finding suggests that contrast utilization is comparable regardless of the access site chosen for PCI.
Aim:
To compare the amount of contrast used during percutaneous coronary intervention (PCI) via trans-radial access (TRA) vs trans-femoral access (TFA).
Methods:
Scientific databases and websites were searched for:randomizedcontrolledtrials (RCTs). Data were extracted by two independent reviewers and was summarized as the weighted mean difference (WMD) of contrast used with a 95%CI using a random-effects model.
Results:
The meta-analysis included 13 RCTs with a total of 3165 patients. There was no difference between the two strategies in the amount of contrast used (WMD = - 0.65 mL, 95%CI: -10.94-9.46 mL; P = 0.901).
Conclusion:
This meta-analysis shows that in patients undergoing PCI, the amount of contrast volume used was not different between TRA and TFA.
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