Caffey's Disease Sans Mandibular and Clavicular Involvement: A Rare Case Report

Area of Science:

• Pediatric medicine
• Genetics
• Skeletal dysplasias

Background:

• Infantile Cortical Hyperostosis (Caffey's disease) is a rare, benign inflammatory disorder affecting infants.
• It is characterized by bone changes, soft tissue swelling, and irritability.
• Typical bone involvement includes the mandible, clavicles, and ulnae.

Observation:

• A 5-month-old male infant was diagnosed with Infantile Cortical Hyperostosis.
• The patient presented with an atypical pattern of bone involvement.
• Mandibular and clavicular involvement, commonly seen in this condition, were notably absent.

Findings:

• The case demonstrates a rare variant of Infantile Cortical Hyperostosis.
• This presentation deviates from the typical skeletal sites affected by the disease.
• The diagnosis was confirmed despite the absence of classic mandibular and clavicular lesions.

Implications:

• This unusual presentation expands the known spectrum of Infantile Cortical Hyperostosis.
• It underscores the importance of considering atypical manifestations in diagnosing rare pediatric disorders.
• Further research may elucidate genetic or environmental factors contributing to varied disease expression.