Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

437
Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
437
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

503
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
503
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

301
A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
301
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

402
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
402

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ventral coxofemoral luxation in poodle breeds: multicentre retrospective case series.

The Journal of small animal practice·2026
Same author

Cumulative gonadal hormone exposure is nonlinearly associated with risk of canine cranial cruciate ligament disease: a generalised additive model analysis of 20,590 dogs (1988-2023).

The Journal of small animal practice·2025
Same author

Use of jejunal serosal patch and pyloric exclusion in the management of complex duodenal injury.

Annals of the Royal College of Surgeons of England·2024
Same author

Abstracts of presentations to the Annual Meetings of the Canadian Society of Colon and Rectal Surgeons Canadian Association of General Surgeons Canadian Association of Thoracic Surgeons: Canadian Surgery Forum, Toronto, Ont., September 6-9, 2007.

Canadian journal of surgery. Journal canadien de chirurgie·2023
Same author

Dietary isoleucine supplementation enhances growth performance, modulates the expression of genes related to amino acid transporters and protein metabolism, and gut microbiota in yellow-feathered chickens.

Poultry science·2023
Same author

Modelling nitrogen-corrected apparent metabolisable energy requirement for egg production of 3 BW types of Yellow Broiler breeder hens during the egg-laying period.

Animal : an international journal of animal bioscience·2022
Same journal

Correction to "On the shape of the radiation survival curve in tumor spheroids: The role of oxygen heterogeneity".

Medical physics·2026
Same journal

Multi-view constrained semi-supervised vertebra detection for 3D ultrasound spine volume.

Medical physics·2026
Same journal

Accuracy of quantitative <sup>177</sup>Lu SPECT/CT imaging: A systematic review.

Medical physics·2026
Same journal

Physics-constrained dual-domain network for CBCT reconstruction from orthogonal X-rays in gynecologic radiotherapy.

Medical physics·2026
Same journal

Decomposition-based harmonization for quantitative PET imaging across scanners and radiotracers.

Medical physics·2026
Same journal

Development and evaluation of an in vivo dose-based monitoring system for electron FLASH radiation therapy.

Medical physics·2026
See all related articles

Related Experiment Video

Updated: Mar 2, 2026

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

3.3K

SU-E-T-613: Improving Dose-Shaping and OAR-Sparing Using Robust Statistical Methods.

G Sayre1, D Low1, D Ruan1

  • 1UCLA, Los Angeles, CA.

Medical Physics
|May 19, 2017
PubMed
Summary
This summary is machine-generated.

This study introduces a new method for intensity-modulated radiation therapy (IMRT) optimization, improving tumor coverage and organ-at-risk (OAR) sparing in prostate cancer treatment.

Keywords:
CancerIntensity modulated radiation therapyOptimizationStatistical methodsSurface dynamicsSurface structure

More Related Videos

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

16.3K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.2K

Related Experiment Videos

Last Updated: Mar 2, 2026

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

3.3K
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

16.3K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.2K

Area of Science:

  • Medical Physics
  • Radiation Oncology

Background:

  • Intensity-modulated radiation therapy (IMRT) is a cornerstone of modern radiation oncology.
  • Optimizing IMRT plans to balance tumor coverage and organ-at-risk (OAR) sparing remains a challenge.

Purpose of the Study:

  • To develop and evaluate a novel robust statistical method for IMRT inverse optimization.
  • To improve the balance between target volume (PTV) coverage and OAR sparing.

Main Methods:

  • A new approach minimizing the L1 norm of dose discrepancy and total variation of the dose distribution on PTV and OARs.
  • This method promotes sparse high-dose gradients, dose homogeneity, and connectivity of high-gradient voxels.
  • Comparison of a novel plan (plan_r) against a clinical plan (plan_c) for a dynamic IMRT prostate case using dose-volume histograms and dose maps.

Main Results:

  • The novel plan (plan_r) demonstrated improved dose conformity compared to the clinical plan (plan_c).
  • Plan_r achieved significantly better bladder and rectum sparing.
  • The method resulted in sparsely-distributed high-dose gradients and improved dose homogeneity.

Conclusions:

  • Robust formulations in IMRT optimization can effectively enhance dose shaping and OAR sparing.
  • The proposed method's numerical stability and simplicity facilitate clinical implementation.