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A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics

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SU-E-T-273: Commissioning Motorized Jaws for a Micro-CT/RT.

M Jensen^1,2,3, T Hrinivich^1,2,3, M Drangova^1,2,3

¹The University of Western Ontario, London, ON, CA.

Medical Physics

|May 19, 2017

Summary

This summary is machine-generated.

Computer-controlled motorized jaws were developed for micro-CT guided radiotherapy in small animals. These jaws achieve reliable sub-millimeter positioning, enabling precise conformal treatments.

Keywords:

Calibration Computed tomography Dosimetry Field size Germanium Image scanners Ionization chambers Medical imaging Monte Carlo methods Radiation therapy

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Area of Science:

Medical Physics
Preclinical Imaging
Radiotherapy Technology

Background:

Micro-computed tomography (micro-CT) is crucial for preclinical imaging.
Image-guided radiotherapy (IGRT) requires precise beam delivery systems.
Small animal models are vital for studying radiation effects and testing therapies.

Purpose of the Study:

To design, construct, and commission computer-controlled motorized jaws for a micro-CT system.
To enable conformal image-guided small animal radiotherapy.
To evaluate the performance and precision of the developed jaw system.

Main Methods:

Developed custom motorized orthogonal jaws for a GE eXplore CT 120 preclinical imaging system.
Independently driven x-direction jaws and symmetric y-direction jaws with backup encoders.
Measured beam profiles using EBT2 film and output factors with a Farmer ion chamber.
Created Monte Carlo simulations in BEAMnrc and DOSXYZnrc for comparison.

Main Results:

Ion chamber measurements agreed with Monte Carlo simulations within 2% for relative output factors.
Film measurements showed good agreement with simulations for penumbra widths.
Achieved an average random positioning error of less than 0.1 mm for the jaws.

Conclusions:

The developed computer-controlled motorized jaws offer reliable sub-millimeter positioning accuracy.
The system is poised for implementation in conformal radiotherapy for small animals.
Further refinement of calibration points will enhance absolute jaw positioning accuracy.