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Related Experiment Video

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Quantification of Hydrogen Concentrations in Surface and Interface Layers and Bulk Materials through Depth Profiling with Nuclear Reaction Analysis
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SU-E-T-234: LET Measurement Using Nuclear Emulsion and Monte Carlo Simulation for Proton Beam.

J Shin1,2,1,3,4,5,6, S Cho1,2,1,3,4,5,6, S Park1,2,1,3,4,5,6

  • 1National Cancer Center, Goyang, Gyeonggi-do.

Medical Physics
|May 19, 2017
PubMed
Summary

This study validates the use of nuclear emulsion films to measure linear-energy-transfer (LET) in proton therapy beams. The findings confirm the accuracy of GEANT4 simulations for assessing biological effects on tissues.

Keywords:
CancerCarbonEmulsionsMonte Carlo methodsMusical performanceNuclear emulsionsProton therapyProtonsTherapeuticsTissues

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Particle Therapy

Background:

  • Particle therapy, including proton and carbon ion treatments, relies on understanding the biological effects on tumors and normal tissues.
  • Linear-energy-transfer (LET) is a critical factor closely linked to these biological effects.

Purpose of the Study:

  • To present a Monte Carlo study using GEANT4 and verify it with Nuclear Emulsion to determine LET for a proton beam.
  • To assess the biological effect of proton therapy on tissues by measuring LET.

Main Methods:

  • Utilized GEANT4 simulations under experimental conditions for a proton beam with a 14cm Bragg peak range.
  • Employed nuclear emulsion films, interleaved with tissue-equivalent absorbers, to reconstruct proton tracks at low (entrance) and high (Bragg peak) LET regions.
  • Irradiated emulsion packs with a therapeutic proton beam at the National Cancer Center (NCC).

Main Results:

  • Successfully reconstructed proton tracks from scanned nuclear emulsion films.
  • Obtained LET distributions in both low and high LET regions, showing good agreement with GEANT4 simulation results within standard deviation.
  • Determined the relative biological effectiveness (RBE) distribution using the measured LET for the proton beam.

Conclusions:

  • Measured LET at the entrance and Bragg peak regions for the NCC proton beam using both Monte Carlo simulations and nuclear emulsion films.
  • Demonstrated the efficacy of nuclear emulsion films for accurate LET observation.
  • Confirmed the successful application of this method in the medical field for particle therapy assessment.