MO-A-213AB-01: Potential for Focused Low Energy X-Ray Beam for Therapy

Megavoltage photon beams are typically used for therapy because of their skin sparing effect. However, a focused low-energy x-ray beam would also be skin sparing, and would have a higher dose concentration at the focal spot. Such a beam can be produced with polycapillary optics. MCNP5 was used to model dose profiles for a scanned focused beam, using measured beam parameters. The potential of low energy focused x-ray beams for radiation therapy was assessed.

A polycapillary optic was used to focus the x-ray beam from a tungsten source. The optic was characterized and measurements were performed at 50 KV. PMMA blocks of varying thicknesses were placed between optic and the focal spot to observe any variation in the focusing of the beam after passing through the tissue-equivalent material. The measured energy spectrum was used to model the focused beam in MCNP5. A source card (SDEF) in MCNP5 was used to simulate the converging x-ray beam. Dose calculations were performed inside a breast tissue phantom.

The measured focal spot size for the polycapillary optic was 0.2 mm with a depth of field of 5 mm. Focusing was found to remain unchanged through 40 mm of phantom thickness. The calculated depth dose curve inside the breast tissue showed a dose peak several centimeters below the skin with a sharp dose fall off around the focus. The percent dose falls below 10% within 5 mm of the focus. Rotating the optic during scanning preserves the skin-sparing effect of the focused beam.

Low energy focused x-ray beams could be used to irradiate tumors inside soft tissue within 5 cm of the surface.