Related Experiment Video
Updated: Mar 2, 2026
09:30
Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
Published on: December 18, 2016
20.2K
SU-E-I-66: Is T2 Individual Correction in MRS for Fat Quantification Tool Necessary?
C Garrido Salmon1,2, H Trad1,2, F Domenici1,2
1University of São Paulo, FFCLRP, Ribeirão Preto, Brazil.
Medical Physics
|May 19, 2017
Summary
Generic T2 correction is adequate for nonalcoholic steatohepatitis (NASH) fat quantification. A good signal-to-noise ratio is more crucial than precise T2 values for accurate magnetic resonance spectroscopy (MRS) fat fraction calculation.
Area of Science:
- Radiology
- Medical Imaging
- Biophysics
Background:
- Accurate fat quantification is essential for diagnosing and managing nonalcoholic steatohepatitis (NASH).
- Magnetic Resonance Spectroscopy (MRS) is a key in vivo technique for measuring liver fat.
- T2 correction is vital for MRS accuracy but can be time-consuming.
Purpose of the Study:
- To evaluate the efficacy of generic T2 correction for fat quantification in NASH patients.
- To determine if individual T2 value measurements are necessary for routine clinical practice.
Main Methods:
- 19 NASH patients underwent MRI with 3.0T scanner using 3P-Dixon and MRS (PRESS acquisition).
- MRS data acquired at single and multiple echo times (TE).
- Fat quantification compared between generic T2 correction, individual T2 correction, and 3P-Dixon method.
Main Results:
- Individual T2 values for fat and water were estimated.
- MRS fat fraction correlated with 3P-Dixon: 0.75 (individual T2) and 0.82 (generic T2).
- Generic T2 correction showed a higher correlation with the Dixon method.
Conclusions:
- Generic T2 correction is sufficient for NASH fat quantification, prioritizing signal-to-noise ratio over precise T2 values.
- Low variability in T2water suggests minimal iron deposition in this NASH cohort.
- Individual T2 correction is not essential in NASH patients with low iron content.
